In a groundbreaking discovery, Dr. Debabrata Dutta, a Bengali scientist affiliated with the University of Massachusetts Medical School, has unravelled the mysteries surrounding the intricate structure of the human cardiac muscles. This significant breakthrough, published in the prestigious international science journal 'Nature' and its news department, 'Nature News and Views,' sheds light on the unknown realms within the human heart.
The research explores the complex molecular arrangement of actin filaments and myosin filaments in the heart, responsible for the rhythmic 'lub-dub' sound of our heartbeat. While scientists have long understood the atomic structure of actin filaments, the details of myosin filaments have remained elusive until now.
Dr. Debabrata Dutta, a native of the jungle region of Bankura, West Bengal, and a former student of IIT Kharagpur, along with his research team, employed cutting-edge technology such as cryo-electron microscopy and artificial intelligence to decipher the molecular architecture of myosin filaments in the human heart. This discovery marks a significant advancement in understanding the intricate dance of actin and myosin proteins, creating the rhythmic 'lub-dub' heartbeat.
Speaking to the media, Dr. Debabrata Dutta emphasized the importance of the team's findings, stating that the use of cryo-electron microscopy and AI has allowed them to unveil the complex structure of myosin, titin, and myosin-binding proteins, forming a crucial component of cardiac architecture.
Born and raised in Bankura, Dr. Dutta's journey from Bankura Christian College to St. Xavier's College in Kolkata and later pursuing advanced studies in biotechnology at IIT Kharagpur reflects his early passion for becoming a prominent scientist. After completing his PhD in the United States in 2019, Dr. Dutta conducted research at the National Institute of Health and later joined the laboratory of Dr. Roger Craig in the Radiology Department at the University of Massachusetts Medical School.
This achievement not only contributes to the global understanding of cardiac biology but also serves as a testament to the capabilities of Bengali scientists on the international stage. Dr. Debabrata Dutta's breakthrough has undoubtedly set a new benchmark in the field of cardiac science, showcasing that when Bengalis set their minds to it, they can indeed achieve the extraordinary.